How old can a person live to - scientists answer
Researchers have built a mathematical model to determine the theoretical limit of human lifespan, driven by the accumulation of somatic mutations in DNA. Even if all age-related diseases are eliminated, random mutations will continue to accumulate and limit cell function. Calculations show that the median lifespan in this scenario could be 146–194 years. Brain and heart cells, which hardly renew themselves, are named as the main natural limitation.
Researchers have built a mathematical model to determine the theoretical limit of human lifespan, driven solely by the accumulation of somatic mutations in DNA. Even with the complete elimination of all known age-related diseases, random mutations that occur with each cell division will continue to accumulate. Over time, their number may reach a level where cells lose the ability to maintain normal body function. Calculations show that the median lifespan in this hypothetical scenario could range from 146 to 194 years. This is roughly double the average lifespan under favorable conditions (about 79 years). The authors emphasize that this is a thought experiment, not a prediction. The key limitation is identified as long-lived brain and heart cells, which are hardly replaced and continue to accumulate mutations, unlike skin and liver cells that can regularly renew themselves.