Which popular food supplement may increase cancer risk
American and Swedish scientists have discovered that antioxidants, traditionally considered a protection against cancer, may actually contribute to the spread of metastases. Researcher Martin Bergo found that taking vitamin E as a supplement increases the risk of lung cancer progression due to its effect on the BACH1 protein. Experiments on mice and human tissue showed that excess antioxidants stabilize BACH1, promoting aggressive tumor growth.
American and Swedish scientists have discovered that antioxidants, traditionally considered an important element in the prevention of cancer, may instead contribute to the spread of metastases. Researcher Martin Bergo found that taking vitamin E as a dietary supplement increases the likelihood of lung cancer progression. This is linked to its effect on the BACH1 protein, which plays a key role in the mechanisms of malignant cell migration. Previously, vitamin E was believed to have a pronounced protective effect against cancer, but new data call this into question. Experiments on laboratory mice and human tissue revealed processes by which cancer cells protect themselves from toxic effects arising during their intensive growth. The BACH1 protein turned out to be a central element of the signaling system regulating the spread of tumor cells and their penetration into healthy tissues. Scientists also found that in undifferentiated non-small cell lung cancer, mutations occur that enhance the activity of the NRF2 protein. This protein stimulates the production of antioxidants while reducing levels of compounds responsible for the formation of reactive oxygen species. Normally, these molecules cause oxidative stress, which can destroy malignant cells. However, excessive intake of antioxidants leads to the BACH1 protein remaining stable and promoting aggressive tumor spread. These discoveries question the unconditional benefit of antioxidant supplements for cancer patients. Doctors recommend caution with high doses of vitamin E and other antioxidants without medical indications.