The body can accelerate its own aging: scientists reveal a hidden mechanism

Researchers have described a mechanism where the accumulation of senescent cells can accelerate tissue aging. DNA damage triggers a protective response, but chronic accumulation causes these cells to release inflammatory molecules, creating a vicious cycle. Scientists are studying senolytics to remove these cells, but their use in humans has not yet been proven.

Researchers have described a mechanism where the accumulation of senescent cells (senescence) can accelerate tissue aging. DNA damage triggers a protective response: the cell stops dividing to prevent the transmission of genetic defects. However, with chronic accumulation, such cells release inflammatory molecules (SASP), creating a vicious cycle—age-related changes hinder their removal, and their activity worsens tissue condition. Scientists are studying senolytics—substances capable of selectively destroying senescent cells. In animal experiments, they have shown promising results, but translation to humans requires further research. The main challenge: senescent cells are involved in wound healing and protection against tumors, so their complete elimination could disrupt important biological processes. The article notes that aging is a complex process involving changes in mitochondria, metabolism, and regenerative capabilities. A healthy lifestyle (physical activity, sleep, nutrition) helps reduce the risk of chronic diseases but cannot completely stop cellular aging.