Scientists search for obesity treatments that preserve muscle and prevent weight regain

Researchers are calling for the development of a new generation of obesity drugs that preserve muscle mass and prevent weight regain, according to scientific reviews published in the journal Science and reported by Al-Sharq. The reviews warn that current drugs, despite their success in weight loss, are associated with muscle loss, digestive side effects, and the possibility of regaining weight after discontinuation.

Researchers are calling for the development of a new generation of obesity drugs that not only reduce weight but also help preserve muscle, improve adipose tissue function, and reduce metabolic disorders associated with obesity. This comes from recent scientific reviews published in the journal Science and reported by Al-Sharq. The reviews warn that the success of current obesity drugs in helping millions of patients lose weight does not eliminate health challenges, most notably muscle loss, gastrointestinal side effects, and the possibility of regaining some lost weight after stopping treatment. Co-author Matthias Blüher explained that the ability of these drugs to achieve significant weight loss does not necessarily guarantee sustainable health outcomes, given varying patient responses and the potential for side effects or weight regain after discontinuation. Muscle loss is a key challenge, as successful obesity treatment is measured not only by kilograms lost but also by the type of tissue lost and the preservation of strength and physical function.